ABSTRACT
Objective:To analyze the needs and recommendation of nurses in level3 general hospital for the application scenarios of nursing robots, so as to provide a basis for the design of intelligent machine systems to reduce the workload of nurses in the hospitals.Methods:Using phenomenological research methods, a total of 17 clinical nurses from Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Zhongda Hospital Southeast University and the First People′s Hospital of Lianyungang from November 2021 to March 2022 were selected for semi-structured interviews. Colaizzi content analysis method was used to sort out the data.Results:Clinical nurses′requirements for application scenarios of nursing robots could be summarized into four themes: feasibility of clinical application of robot recognized by nurses; expected alternative care scenarios; summary of nursing robot design features; multiple factors limit the application of nursing robots.Conclusions:Clinical nurses have diverse requirements for the application scenarios of nursing robots, and only part of non-clinical tasks will be authorized to robots in a short period of time. In the face of future opportunities and challenges, with the help of policies, legal supervision should be strengthened, so as to improve the reliability and safety of clinical application of nursing robots.
ABSTRACT
Transforming growth factor β(TGF-β)superfamily ligands play an important role in regulating cellular homeostasis including proliferation,differentiation,apoptosis,immune sur-veillance and angiogenesis.Type Ⅲ TGF-βreceptor (TβRⅢ) is considered to be the coreceptor of TGF-βsuperfamily.TβRⅢnot only has an effect on classical Smad signaling pathway,but also on non-Smad signaling pathway.TβRⅢplays a crucial role in fibrosis,tumor,cardiovascular diseases via mediating kinds of signaling pathways.This paper reviews TβRⅢ mediated sig-naling pathway and its role in fibrotic diseases.
ABSTRACT
β-arrestins, a kind of important adaptor protein and signal transduction protein found in the purification process ofβ-adrenergic receptor kinase (β-ARK) ,were first identified as pro-teins that have the ability to desensitize G protein-coupled recep-tors ( GPCR) . Fibrosis is defined by the overgrowth, hardening, and scarring of various tissues and is attributed to excess deposi-tion of extracellular matrix ( ECM ) components including colla-gen . A large number of studies have shown thatβ-arrestins play an important role in the process of fibrotic diseases, involved in inflammatory response and excess deposition of ECM. This re-view discusses the research status and development prospects ofβ-arrestins-mediated fibrotic diseases.